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The De Materia Medica of Dioscorides, written around 70 A.D., was the most important source of information on medicinal plants for 1500 years and today remains an important text in this field. The oldest known complete manuscript is the Juliana Anicia Codex (ca. 512 A.D.), housed in the Austrian National Library in Vienna. Listed as Codex Vindobonensis Medicus Graecus 1., it is better known as the Vienna Dioscorides, the oldest and most valuable work in the history of botany and pharmacology.
New plant discoveries in the 16th century led to a reappraisal of Dioscorides. The most important were the commentaries of Pietro Andreas Mattioli, a doctor and naturalist born in Siena in 1501. Pietro became so obsessed with Dioscorides that with each new edition his commentaries grew ever longer. He established an international reputation and was appointed personal physician to the Hapsburg Emperor Ferdinand I. In Prague he met Ogier Ghiselin de Busbecq who served as the Emperor’s ambassador to Constantinople from 1555 to 1562. Busbecq told him of the magnificent manuscript of Dioscorides he had seen at the Ottoman court, which he was later able to acquire for Ferdinand.
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